Coiled Coils

Predict protein coiled coil regions

Coiled Coils Plugin

Compare your sequence to a database of known parallel two-stranded coiled-coils and derive a similarity score. By comparing this score to the distribution of scores in globular and coiled-coil proteins, you can then calculate the probability that the sequence will adopt a coiled-coil conformation.

By Tobias Thierer

Quick Start

Install the plugin by downloading the gplugin file and dragging it in to Geneious or use the plugin manager in Geneious (under Tools - Plugins in the menu).

Once installed, select a protein sequence and the Coiled Coils graph will appear. The graph has three lines corresponding to different sliding window sizes: Green = 14, Blue = 21, Red = 28. Options are available on the Graphs tab of the controls to the right of the Sequence view.


1.1.1 (04 Dec 2009) – Download

– Now gives identical results to coils2

– Fix issue with sequences with fewer than 28 residues


Lupas, A., Van Dyke, M., and Stock, J. (1991) Predicting Coiled Coils from Protein Sequences, Science 252:1162-1164. Links


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