CpG Islands

CpG Islands Plugin

DNA methylation is an important part of gene regulation as it can prevent proteins binding to a gene in transcription. Using the Hidden Markov models described by Richard Durbin, the CpG Plugin will generate a nucleotide sequence graph which will predict how likely a region of your sequence is a possible methylation site.

By Tobias Thierer

Quick Start

Install the plugin by downloading the gplugin file and dragging it in to Geneious or use the plugin manager in Geneious (under Tools - Plugins in the menu).

Once installed, select a nucleotide sequence and the CpG island graph will appear. Options are available on the Graphs tab of the controls to the right of the Sequence view.

History

1.1 (18 Sep 2008) – Download

– Improved graph drawing on circular sequences in Geneious 4.0+