Automatically annotate proteins with InterPro domains
Requires Geneious Prime 2019+ (Windows & Linux) and Geneious Prime 2021.1 (MacOS)+

InterProScan Plugin

InterProScan is a tool to automatically annotate proteins with families and domains. It runs the search tools of the databases included in InterPro, (hmmer, ProfileScan and others) and then maps the search results to entries in the InterPro database.

By Michael Thon

Quick Start

Install the plugin by downloading the gplugin file and dragging it in to Geneious Prime or use the plugin manager in Geneious (under Tools - Plugins in the menu).

Once installed, run the plugin by selecting a protein sequence and choosing Annotate & Predict - Find protein domains with InterProScan from the menu. Results are saved as annotations on your sequence.


2.1.0 (09 Oct 2023) – Download

  • Fixed InterProScan by using a new REST API

2.0 (09 Jul 2021) – Download

  • Fixed InterProScan by using a new REST API
  • Compatible with Geneious Prime 2019+ on Windows and Linux
  • Compatible with Geneious Prime 2021.1+ on MacOS


Quevillon E., Silventoinen V., Pillai S., Harte N., Mulder N., Apweiler R., Lopez R. (2005).InterProScan: protein domains identifier.Nucleic Acids Res. 33 (Web Server issue): W116-W120


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